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$40 USD / hour
Flag of CANADA
kingston, canada
$40 USD / hour
It's currently 3:59 AM here
Joined February 23, 2024
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Jithin S.

@jithinsamsunny

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$40 USD / hour
Flag of CANADA
kingston, canada
$40 USD / hour
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Bioinformatician, Data analyst, Creative writing.

As a dedicated and innovative researcher in the field of biology, my work spans across a diverse range of studies focused on leveraging computational biology, genomics, and bioinformatics to address complex biological questions and medical challenges. A significant aspect of my research prowess is my proficiency in Python and R, programming languages that are indispensable in the field of data analysis. My expertise extends beyond traditional data analysis to encompass technical skills in shell scripting, and setting up sophisticated software pipelines. I have demonstrated a keen aptitude for developing innovative solutions by creating specialized databases and Python-based tools tailored to the needs of my project too. My current project involves employing machine learning techniques to classify proteins based on their individual amino acids, a groundbreaking approach that enhances our understanding of plastic degradation. This work is characterized by the handling of vast datasets on powerful servers, showcasing my ability to manage and analyze large-scale biological data efficiently. Additionally, I am an avid writer with several blogs to my name, where I explore the intersections of bioinformatics, computational biology, and current research trends, further showcasing my ability to communicate complex scientific concepts to a broader audience. For further insights into my projects and contributions, please connect with me on LinkedIn and explore my repositories on GitHub, where I regularly update my ongoing work and share resources with the scientific community.

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Experience

Bioinformatician

FIND
Feb 2022 - Jan 2023 (11 months, 4 days)
I was responsible for setting up workflows for nanopore sequencing of COVID surveillance.

Education

Ph.D.

India 2017 - 2023
(6 years)

Publications

Analysis of R-loop modulated epigenetic regulation in T helper cells

Elsevier
Some common epigenetic regulations exist between coronary artery disease (CAD) and non-small cell lung cancer (NSCLC). Using Bioinformatics pipeline and graph network analysis, several DNA damage-repair factors (e.g., BRCA1, ERCC1, XPF, RAD51 etc.) and R-loops involved in CAD and NSCLC diseases were identified and then proved in-vitro.

Anomaly detection framework for wearables data

MDPI
In this article, we review the nature of the wearables-associated data and the downstream processing methods for detecting anomalies. In addition, we also review supervised and un-supervised techniques as well as semi-supervised methods that overcome the challenges of missing and un-annotated healthcare data.

SPEdit: A sequence repository and a random forest classification based platform for serine protease

AIJR Abstracts
Although successful protein engineering of this enzyme is being reported, increasing protein sequence information can aid in better rational protein designing endeavours. SPEdit is a web based platform that acts both as a data repository for serine proteases and also aid the analysis of user-provided sequence for the same. As a repository, SPEdit includes enzymes extracted from over 170 thermophilic bacterial genomes that are currently available from NCBI.

Converting the genomic knowledge base to build protein specific machine learning prediction models

Springer International Publishing
We built a using 283 thermophilic and 200 mesophilic bacterial genomes. Features were extracted from 760 sequences, followed by feature selection. We deployed a random forest-based classifier that identified thermophilic and non-thermophilic serine proteases with an accuracy of 97.11%, higher than other benchmark machine learning methods. This study showcased the use of amino acid positional shifts to build accurate downstream protein engineering techniques.

IND-enzymes: a repository for hydrolytic enzymes with potential industrial usage

Springer International Publishing
Based on more than 100 publications and genomes from over 300 thermophilic and psychrophilic bacterial species, we have constructed the database IND-Enzymes (indenzymes.srmist.edu.in). This database consists of over 20,120 nucleotide and protein sequences belonging to the hydrolytic enzyme class lipase, protease, esterase and amylase. Users can access over 100 published enzymes, 200 PDB structural data, along with an alignment tool and python based pipelines.

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